Panax notoginseng, a key ingredient in traditional Chinese medicine, has attracted growing interest for its effects on stem cell activity.
Known for its saponin-rich composition, panax notoginseng offers a range of biological actions, including enhanced proliferation, immune support, and protective effects on cells.
This article focuses on how panax notoginseng and its components, especially panax notoginseng saponins (PNS), support stem cell release, function, and survival.
What Is Panax Notoginseng?
Panax notoginseng is a species of ginseng. Its roots are widely used in Chinese medicine. The main active compounds include panax notoginseng saponins, ginsenoside Rg1, and various polysaccharides from panax notoginseng.
Major Active Components
| Component | Function |
|---|---|
| Panax notoginseng saponin | Supports proliferation and cell function |
| Ginsenoside Rg1 | Promotes cell cycle progression and stem cell activity |
| Polysaccharide from panax notoginseng | Enhances immune response and cell activity |
Stem Cell Activity and Panax Notoginseng
Panax notoginseng influences stem cells in several key ways. It stimulates proliferation, supports differentiation, and protects against cell death.
Stem Cell Proliferation
Research shows that panax notoginseng and its saponins increase the proliferation of human stem cells, especially mesenchymal stem cells and neural stem cells.
Data from studies:
| Study Model | Result |
|---|---|
| rat hippocampal neural stem cells | PNS promoted proliferation and differentiation |
| bone marrow mesenchymal stem cell | Increased cell proliferation under PNS treatment |
| human adipose-derived stem cells | Improved cell activity and reduced cell death |
The effect of panax notoginseng saponins on proliferation is significant. It can significantly increase the number of circulating stem cells.
Differentiation and Cell Protection
PNS affects the cell cycle and encourages cell differentiation. It also has a protective effect against aging and cell senescence-associated diseases.
Key Findings
- Panax notoginseng saponins combined with other herbs enhance proliferation and the expression of growth factors.
- Ginsenoside Rg1 and ginsenoside-Rd from panax notoginseng protect cortical neural stem cells and cultured rat hippocampal neurons.
- Saponins of panax protect cells by influencing the signal pathway responsible for cell growth and survival.
Extracts and Cell Line Results
Different forms of panax notoginseng extract have shown clear benefits in cell culture studies (cells in vitro) and animal models (vitro and in vivo).
Observations:
- Total panax notoginseng saponins improved bone marrow stem cell function.
- Steamed panax notoginseng enhanced the therapeutic effect on non-small cell lung cancer models.
- Raw and steamed panax notoginseng had different impacts on immune response and cell proliferation.
Anti-Cancer and Immune Support Effects
Panax notoginseng also affects cancer cell activity. Its saponins inhibit sw480 human colorectal cancer cells and non-small cell lung growth.
Additional Effects
- PNS improves immune response by activating umbilical vein endothelial cells and positive cells involved in immunity.
- It helps reduce cell death in rat models of brain injury.
- It has an inhibitory effect on cell inflammation and can induce cell survival signals.
Overview of Scientific Data
Table: Summary of Key Biological Effects
| Target | Effect | Source |
|---|---|---|
| Stem cells from the bone marrow | Enhanced proliferation and survival | effect of panax notoginseng |
| Neural stem cells | Protection and proliferation | ginsenoside rg1 |
| Cancer cell lines | Inhibitory effect and apoptosis | saponins inhibit growth |
| Rat hippocampal neurons | Support for cell function and regeneration | panax notoginseng saponins attenuate inflammation |
| Endothelial cell systems | Strengthened barrier and growth | effect of ginsenoside rg1 |
Final Thoughts
Panax notoginseng offers clear benefits for stem cell support.
It improves cell proliferation, enhances survival, and promotes cell differentiation.
These effects contribute to its therapeutic potential in both regenerative support and immune system regulation.
With a strong base in traditional Chinese medicine, panax notoginseng continues to show promise for those interested in natural ways to activate and support stem cell health.
Are you looking for a natural supplement that contains panax notoginseng along with other natural ingredients to support your body’s stem cell release? Consider STEMREGEN.
